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KMID : 0617219910020010023
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Duksung Bulletin Phamaceutical Sciences
1991 Volume.2 No. 1 p.23 ~ p.27
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Synthesis of new potential anti-inflammatory Hydantoin-3-Acetic Acids and their Derivatives
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Abstract
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Through the Bucherer-Bergs method, new 5-alkylthio (sulfonyl)-methyl-p-x-phenylhydantoins were prepared. Hydantoin-3-acetates were synthesized by the reaction of the hydantoins and ethyl chloroacetate and through the subsequent hydrolysis of the 3-acetates with dilute sodium hydroxide hydantoin-3-acetic acids were obtained. These products are expected to exhibit antiinflammatory and analgetic activities.
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